Mouse position messes up remote

I hope this hasn’t been mentioned earlier, but it’s been a minor annoyance to me for some time. I’m currently running the beta 2 Krypton release but it’s been an issue for as long as I can recall.

If I start up Kodi and my mouse pointer happens to be jammed into a corner of the screen the remote buttons (up, down, left, right on a Logitech Harmony Ultimate) will not respond. I have to move the mouse over the screen somewhere else for button presses to register. Anyone else have this issue? My htpc is running Windows 10 Pro x64 (current build), nVidia Geforce gtx980, 16gb RAM, Skylake i7.