V16.1 to V17.1 MySQL Upgrade

Hello,

I have various rpi3 boxes and a few windows 10 boxes running Kodi v16.1, I want to make the jump to v17.1. I’m using mariadb on an unraid server. Do I have to disconnect all boxes from the db server prior to upgrading? Then just upgrade one at a time? Or can they all remain connected while I upgrade one at a time? Thanks,